Perinuclear positioning of the inactive human cystic fibrosis gene depends on CTCF, A-type lamins and an active histone deacetylase.

@article{Muck2012PerinuclearPO,
  title={Perinuclear positioning of the inactive human cystic fibrosis gene depends on CTCF, A-type lamins and an active histone deacetylase.},
  author={Joscha S Muck and Karthikeyan Kandasamy and Andreas Englmann and Martin G{\"u}nther and Daniele Zink},
  journal={Journal of cellular biochemistry},
  year={2012},
  volume={113 8},
  pages={2607-21}
}
The nuclear positioning of mammalian genes often correlates with their functional state. For instance, the human cystic fibrosis transmembrane conductance regulator (CFTR) gene associates with the nuclear periphery in its inactive state, but occupies interior positions when active. It is not understood how nuclear gene positioning is determined. Here, we investigated trichostatin A (TSA)-induced repositioning of CFTR in order to address molecular mechanisms controlling gene positioning… CONTINUE READING
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