Perineurial defect and peripheral opioid analgesia in inflammation.

  title={Perineurial defect and peripheral opioid analgesia in inflammation.},
  author={I A Antonijevic and Shaaban A Mousa and Michael Schaefer and Christoph Stein},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={15 1 Pt 1},
Opioid receptors have been demonstrated on sensory nerves in both inflamed and normal subcutaneous tissue but locally applied opioid agonists produce analgesia in inflamed tissue only. Inflammation confers a disruption of the perineurial barrier that can also be induced deliberately by hyperosmolar solutions. The present study examines at which stage of Freund's adjuvant-induced inflammation peripheral opioid analgesic effects become manifest and whether a perineurial defect contributes to the… CONTINUE READING


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