Perineural invasion is associated with increased relapse after external beam radiotherapy for men with low-risk prostate cancer and may be a marker for occult, high-grade cancer.

@article{Beard2004PerineuralII,
  title={Perineural invasion is associated with increased relapse after external beam radiotherapy for men with low-risk prostate cancer and may be a marker for occult, high-grade cancer.},
  author={Clair J. Beard and Ming Hui Chen and Kerri Cote and Marian J Loffredo and Andrew A Renshaw and Mark Hurwitz and Anthony V. D'Amico},
  journal={International journal of radiation oncology, biology, physics},
  year={2004},
  volume={58 1},
  pages={19-24}
}
PURPOSE To investigate the risk of postradiotherapy prostate-specific antigen (PSA) failure on the basis of pretreatment risk factors in prostate cancer patients with and without perineural invasion (PNI) in prostate biopsy specimens and to explain the observation that otherwise low-risk patients with PNI experience decreased freedom from PSA failure after external beam radiotherapy (RT). METHODS AND MATERIALS The study cohort consisted of 381 patients who underwent RT between 1989 and 2000… CONTINUE READING