• Corpus ID: 239768378

Perineural Invasion Detection in Multiple Organ Cancer Based on Deep Convolutional Neural Network

@article{Nateghi2021PerineuralID,
  title={Perineural Invasion Detection in Multiple Organ Cancer Based on Deep Convolutional Neural Network},
  author={Ramin Nateghi and Fattane Pourakpour},
  journal={ArXiv},
  year={2021},
  volume={abs/2110.12283}
}
Perineural invasion (PNI) by malignant tumor cells has been reported as an independent indicator of poor prognosis in various cancers. Assessment of PNI in small nerves on glass slides is a labor-intensive task. In this study, we propose an algorithm to detect the perineural invasions in colon, prostate, and pancreas cancers based on a convolutional neural network (CNN). 

Figures and Tables from this paper

References

SHOWING 1-7 OF 7 REFERENCES
Prognostic effect of perineural invasion in surgically treated esophageal squamous cell carcinoma
TLDR
This work investigated the prognostic role of perineural invasion in surgically treated esophageal squamous cell carcinoma and found it to be a prognostic factor used in several cancers.
Perineural invasion of cancer: a complex crosstalk between cells and molecules in the perineural niche.
TLDR
The current review aims to elucidate the cellular and molecular mechanisms of PNI, which may help to find a strategy for improving the prognosis of malignant tumors.
Perineural invasion as a prognostic factor in patients with stage I-III rectal cancer – 5-year follow up
TLDR
LVI and PNI were significant factors predicting worse prognosis in early and intermediate RC patients, hence more aggressive therapy should be reserved for these patients after curative resection.
Should reporting of peri-neural invasion and extra prostatic extension be mandatory in prostate cancer biopsies? correlation with outcome in biopsy cases treated conservatively
TLDR
The utility of routinely examining prostate biopsies for ECE and PNI is doubtful as it is not independently associated with higher grade, stage or prognosis.
Perineural invasion as an independent predictor of biochemical recurrence in prostate cancer following radical prostatectomy or radiotherapy: a systematic review and meta-analysis
TLDR
This study suggests that the presence of PNI by histopathology is associated with higher risk of BCR in PCa following RP or RT, and could serve as an independent prognostic factor in patients with PCa.
Nerves and neurotropic carcinomas.
  • J. Batsakis
  • Medicine
    The Annals of otology, rhinology, and laryngology
  • 1985
Neurotropism by a carcinoma in the head and neck refers to invasion in, around, and through peripheral nerves. This invasion may be along planes of least resistance in the connective tissue coverings
Nerves and neurotropic carcinomas." The Annals of otology, rhinology, and laryngology
  • 1985