Perindopril/Amlodipine (Prestalia®): A Review in Hypertension

@article{Shirley2015PerindoprilAmlodipineA,
  title={Perindopril/Amlodipine (Prestalia{\textregistered}): A Review in Hypertension},
  author={Matt Shirley and Paul L. McCormack},
  journal={American Journal of Cardiovascular Drugs},
  year={2015},
  volume={15},
  pages={363-370}
}
Perindopril, an ACE inhibitor, and amlodipine, a dihydropyridine calcium channel blocker, are established antihypertensive agents with complementary mechanisms of action. [] Key Result As demonstrated in short-term randomized controlled trials, perindopril/amlodipine FDC was significantly more effective in reducing blood pressure (BP) than monotherapy with either of the component drugs, and it appeared to be more effective than an up-titration scheme using valsartan and valsartan/amlodipine.

Perindopril/Indapamide/Amlodipine in Hypertension: A Profile of Its Use

TLDR
The single-pill PER/IND/AML has similar efficacy and tolerability to PER/ind/IND + AML given as two separate pills, which may improve adherence to treatment, leading to better BP control and clinical outcomes.

Adherence to Treatment, Safety, Tolerance, and Effectiveness of Perindopril/Amlodipine Fixed-Dose Combination in Greek Patients with Hypertension and Stable Coronary Artery Disease: A Pan-Hellenic Prospective Observational Study of Daily Clinical Practice

TLDR
The perindopril/amlodipine FDC is characterized by high adherence and effectiveness, regardless of previous treatment, and was related to baseline BP levels.

Pharmacokinetic Drug Interaction Between Amlodipine and Tadalafil: An Open-Label, Randomized, Multiple-Dose Crossover Study in Healthy Male Volunteers

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The dose range of the combined administration of tadalafil and amlodipine in the present study was well tolerated by the subjects, and a substantial pharmacokinetic drug interaction was observed with respect to the concentration of tdalafil when administered concomitantly.

Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review

TLDR
Current understanding of how genetic variants account for the observed variability in BP response in patients on first-line antihypertensive drugs, amlodipine and hydrochlorothiazide is described and enhanced.

Practical Applications for Single Pill Combinations in the Cardiovascular Continuum.

TLDR
In ischaemic heart disease, the concept of a preventative polypill has been studied, but its benefits have not been established conclusively, and the combination of ivabradine and beta-blockers has proven efficacy in patients with stable angina pectoris.

Features of antihypertensive and vasoprotective efficiency of combination of valsartan and amlodipine in patients with obesity under different polymorphic variants of CYP2C9 and CYP11B2 genes

TLDR
To evaluate the efficiency of combination antihypertensive therapy with valsartan and amlodipine in patients with arterial hypertension and obesity, depending on the polymorphisms of the CYP2C9 and CYP11B2 genes, research included 80 obese patients.

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity

TLDR
Results indicate that clinical use of S-AML has an advantage not only because of greater pharmacological effect, but also because of fewer side effects and drug–drug interactions with cytochrome P450 substrates due to absence of R-AMl.

Evaluation of pharmacokinetics and safety with bioequivalence of Amlodipine in healthy Chinese volunteers: Bioequivalence Study Findings

TLDR
The aim of this trial was to explore the pharmacokinetics and safety with bioequivalence of orally administered Amlodipine provided by two sponsors in healthy volunteers (HVs).

F. A. KOVALENKO, V. V. SKIBITSKY, A. V. FENDRIKOVA, K. YU. LAZAREV, I. A. LUKONIN EFFICIENCY OF COMBINED ANTIHYPERTENSIVE THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION AND OBESITY DEPENDING ON

  • Medicine
  • 2018
TLDR
Determined interrelation between the efficiency level of the combined antihypertensive therapy with the CYP2C9 gene polymorphism can be considered in cases of insufficient effect of assigned therapy or the uncontrolled character of the arterial hypertension.

VISIT-TO-VISIT BLOOD PRESSURE VARIABILITY IN RURAL MALES WITH ARTERIAL HYPERTENSION: THE POSSIBILITIES OF MODIFYING IN REAL CLINICAL SETTINGS

TLDR
In rural HTN males, at 1yFU, the AHT (based on P/A, with IND addition as required) favored the significant blood pressure VVV reduction in the vast majority of cases.

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