Perinatal switch from synchronous to asynchronous activity of motoneurons: Link with synapse elimination

  title={Perinatal switch from synchronous to asynchronous activity of motoneurons: Link with synapse elimination},
  author={Mario Buffelli and Giuseppe Busetto and Lorenzo Cangiano and Alberto Cangiano},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={13200 - 13205}
Synaptic competition is a basic feature of developing neural connections. To shed light on its dependence on the activity pattern of competing inputs, we investigated in vivo rat motoneuronal firing during late embryonic and early neonatal life, when synapse elimination occurs in muscle. Electromyographic recordings with floating microelectrodes from tibialis anterior and soleus muscles revealed that action potentials of motoneurons belonging to the same pool have high temporal correlation. The… 

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