Perinatal outcome in women treated with progesterone for the prevention of preterm birth: a meta‐analysis

@article{Sotiriadis2012PerinatalOI,
  title={Perinatal outcome in women treated with progesterone for the prevention of preterm birth: a meta‐analysis},
  author={Alexandros Sotiriadis and Stefania I. Papatheodorou and George Makrydimas},
  journal={Ultrasound in Obstetrics \& Gynecology},
  year={2012},
  volume={40}
}
To quantify the effect on perinatal outcome in women treated with progesterone for the prevention of preterm birth. 
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21 Citations
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21 Citations

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The Rebirth of Progesterone in the Prevention of Preterm Labor
TLDR
Progesterone appears to be safe and efficacious in reducing the risk of preterm birth in a select group of high-risk women with prior spontaneous preterm births and those with an ultrasound-confirmed short cervix.
Preterm Delivery of Twins
TLDR
Cervical pessaries might be a non-invasive cost-effective option, but it is mandatory to evaluate vaginal progesterone and cervical pessary in twin gestations with a short cervix in further randomized trials.
Quelle utilisation de la progestérone pour prévenir la prématurité
Prevention of preterm delivery in twin pregnancy.
  • L. Rode, A. Tabor
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2014
Prevention of preterm birth with vaginal progesterone or 17-alpha-hydroxyprogesterone caproate: a critical examination of efficacy and safety.
Prolonged progesterone administration is associated with less frequent cervicovaginal colonization by Ureaplasma urealyticum during pregnancy - Results of a pilot study.
Cervical Length and Progesterone: Contribution of Ultrasonography to Decide To Whom Administer the Progesterone
TLDR
The cervicometry and the assessment of other factors in the cervix, together with the evidences found aid establishing prophylactic measures to avoid preterm births using progestins.
Vaginal Touch versus Transvaginal Ultrasound in the Management of Threatened Preterm Labour at the University Hospital Center of Porto-Novo (Benin)
TLDR
Vaginal touch was also as relevant as transvaginal ultrasound while evaluating the risk of preterm delivery and for the lack of ultrasound in emergency rooms, a good physical examination would be sufficient by its own to decide of an adequate management when there is a threat of pre term delivery.
Progesterone is not the same as 17α-hydroxyprogesterone caproate: implications for obstetrical practice.
Comparison of cervical length in adult and adolescent nulliparae at mid-gestation.
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References

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TLDR
This study investigated the preventive effect of vaginal micronized progesterone in a large population of twin gestations and found it to have a protective effect on preterm delivery.
Vaginal progesterone is associated with a decrease in risk for early preterm birth and improved neonatal outcome in women with a short cervix: a secondary analysis from a randomized, double‐blind, placebo‐controlled trial
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TLDR
To investigate the efficacy of vaginal progesterone to prevent early preterm birth in women with sonographic evidence of a short cervical length in the midtrimester, a large number of studies have found it to be safe and effective.
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TLDR
Progesterone treatment reduces the risk of preterm delivery in high‐risk singleton pregnancies and the preventive effect of vaginal progesterone in high-risk twins is evaluated.
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TLDR
The objective of this trial was to determine whether prophylactic administration of vaginal progesterone reduces the risk of preterm birth in women with a history of spontaneous pre term birth.
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TLDR
Prophylactic vaginal progesterone reduced the rate of preterm labor and preterm delivery in high-risk pregnancies and there was no significant difference in neonatal death between placebo and progester one groups.
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TLDR
Combining individual patient data from different randomized trials has potential to provide valuable, clinically useful information regarding the benefits and potential harms of progestogens in women with twin pregnancy overall and in relevant subgroups.
Progesterone for the prevention of preterm birth in twin pregnancy (STOPPIT) : a randomized, double-blind, placebo-controlled study and meta-analysis EDITORIAL COMMENT
TLDR
It is confirmed that progesterone does not reduce the risk of early preterm birth or intrauterine death in twin pregnancies, and is consistent with previous studies showing that progestogens do not prevent preterm delivery in women with twin pregnancy.
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