Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism

@article{OrozcoSlis2011PerinatalNR,
  title={Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism},
  author={Ricardo Orozco-S{\'o}lis and Rhowena Jane Barbosa Matos and Sandra Lopes de Souza and Isabelle C Grit and Bertrand Kaeffer and Raul Manh{\~a}es de Castro and Francisco Bola{\~n}os-Jim{\'e}nez},
  journal={International Journal of Obesity},
  year={2011},
  volume={35},
  pages={990-1000}
}
Objective:Several lines of evidence indicate that nutrient restriction during perinatal development sensitizes the offspring to the development of obesity, insulin resistance and cardiovascular disease in adulthood via the programming of hyperphagia and reduced energy expenditure. Given the link between the circadian clock and energy metabolism, and the resetting action of food on the circadian clock, in this study, we have investigated whether perinatal undernutrition affects the circadian… CONTINUE READING

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