Perinatal morbidity and mortality in early‐onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)

@article{Lees2013PerinatalMA,
  title={Perinatal morbidity and mortality in early‐onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE)},
  author={Christoph C. Lees and Neil Marlow and Birgit Arabin and Caterina M. Bilardo and Christoph Brezinka and J. B. Derks and J. J. Duvekot and Tiziana Frusca and Anke Diemert and Enrico Maria Ferrazzi and Wessel Ganzevoort and Kurt Hecher and Pasquale Martinelli and Eva Ostermayer and A T Papageorghiou and Dietmar Schlembach and Karl-Theo Maria Schneider and Baskaran Thilaganathan and Tullia Todros and Aleid G van Wassenaer-Leemhuis and Adriana Valcamonico and Gerald H.A. Visser and Hans Wolf},
  journal={Ultrasound in Obstetrics \& Gynecology},
  year={2013},
  volume={42}
}
Few data exist for counseling and perinatal management of women after an antenatal diagnosis of early‐onset fetal growth restriction. Yet, the consequences of preterm delivery and its attendant morbidity for both mother and baby are far reaching. The objective of this study was to describe perinatal morbidity and mortality following early‐onset fetal growth restriction based on time of antenatal diagnosis and delivery. 
Early‐onset fetal growth restriction: A systematic review on mortality and morbidity
TLDR
This systematic review aims to summarize the literature on mortality and morbidity in obstetric condition and studies often only include live‐born neonates with missing rates of antenatal death.
Monitoring, Delivery and Outcome in Early Onset Fetal Growth Restriction
TLDR
The aim of this review is to summarize the available evidence on monitoring, delivery and outcome in early-onset FGR.
Gestational age at diagnosis of early‐onset fetal growth restriction and impact on management and survival: a population‐based cohort study
To investigate the impact of gestational age (GA) at diagnosis of fetal growth restriction (FGR) on obstetric management and rates of live birth and survival for very preterm infants with early‐onset
Infant outcome after active management of early‐onset fetal growth restriction with absent or reversed umbilical artery blood flow
To describe the short‐ and long‐term outcomes of infants with early‐onset fetal growth restriction (FGR) and umbilical artery absent or reversed end‐diastolic flow (AREDF), delivered before 30 weeks'
The association of neonatal morbidity with long‐term neurological outcome in infants who were growth restricted and preterm at birth: secondary analyses from TRUFFLE (Trial of Randomized Umbilical and Fetal Flow in Europe)
TLDR
To study the relationship between neonatal morbidity (NNM) and two‐year neurodevelopmental impairment (NDI) in surviving children after early fetal growth restriction (FGR), a large number of children are enrolled in the neonatal intensive care unit.
Outcome of early‐onset fetal growth restriction with or without abnormal umbilical artery Doppler flow
TLDR
The objective of this study was to analyze the time interval from admission to delivery of pregnancies with early‐onset fetal growth restriction, while pursuing a policy of postponing delivery unless active management of labor would be required because of fetal distress or maternal condition.
Predictors of perinatal outcome in early‐onset fetal growth restriction: A study from an emerging economy country
TLDR
To identify antenatal predictors of adverse perinatal outcomes in a population of preterm fetuses with early placental insufficiency diagnosed by Doppler abnormalities, a large number of these fetuses have had at least one miscarriage.
Predictors of perinatal outcome in early -onset fetal growth restriction: a study from an emerging economy country.
TLDR
G gestational age and fetal weight, or a combination of fetal weight z-scores and fetal Doppler parameters, were the best predictors of intact survival in this sample of singleton pregnant women diagnosed with early placental insufficiency.
Fetal hemodynamics and adverse outcome in primary school‐aged children with fetal growth restriction: a prospective longitudinal study
TLDR
It is hypothesized that adverse outcome in children with fetal growth restriction at primary school age is associated with fetoplacental circulatory abnormalities.
Early onset fetal growth restriction.
  • A. Nawathe, C. Lees
  • Medicine
    Best practice & research. Clinical obstetrics & gynaecology
  • 2017
...
...

References

SHOWING 1-10 OF 24 REFERENCES
Early intervention in management of very preterm growth‐restricted fetuses: 2‐year outcome of infants delivered on fetal indication before 30 gestational weeks
To describe the outcome of growth‐restricted fetuses with absent or reversed end‐diastolic flow (ARED) in the umbilical artery delivered on fetal indication before 30 gestational weeks.
Predictors of Neonatal Outcome in Early- Onset Placental Dysfunction
TLDR
This study provides neonatal outcomes specific for early-onset placenta-based fetal growth restriction quantifying the impact of gestational age, birth weight, and fetal cardiovascular parameters.
Predictors of outcome at 2 years of age after early intrauterine growth restriction
  • H. Torrance, M. Bloemen, G. Visser
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2010
TLDR
To examine the relative importance of antenatal and perinatal variables on short‐ and long‐term outcome of preterm growth restricted fetuses with umbilical artery Doppler abnormalities, a large number of patients with these abnormalities are surveyed.
Monitoring of fetuses with intrauterine growth restriction: a longitudinal study
  • K. Hecher, C. Bilardo, G. Visser
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2001
To describe the time sequence of changes in fetal monitoring variables in intrauterine growth restriction and to correlate these findings with fetal outcome at delivery.
A randomised trial of timed delivery for the compromised preterm fetus: short term outcomes and Bayesian interpretation.
TLDR
The lack of difference in overall mortality suggests that clinicians participating in this trial were on average prepared to randomize at about the correct equivocal threshold between delivery and delay, however, there was insufficient evidence to convince enthusiasts for either immediate or delayed delivery that they were wrong.
Neonatal and infant outcome in boys and girls born very prematurely
TLDR
It is concluded that in very preterm infants, male sex is an important risk factor for poor neonatal outcome and poor neurological and respiratory outcome at follow-up and lend support to the concept of male vulnerability following preterm birth.
Cardiotocogram compared to Doppler investigation of the fetal circulation in the premature growth‐retarded fetus: longitudinal observations
  • K. Hecher, B. Hackelöer
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 1997
It was our objective to compare computerized fetal heart rate analysis with blood flow velocity waveform analysis of the arterial and venous fetal circulation in intrauterine growth retardation. We
...
...