Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats: implication in psychiatric disorders of developmental origin

@article{Tohmi2004PerinatalIC,
  title={Perinatal inflammatory cytokine challenge results in distinct neurobehavioral alterations in rats: implication in psychiatric disorders of developmental origin},
  author={Manavu Tohmi and Noriko Tsuda and Yuichiro Watanabe and Akiyoshi Kakita and Hiroyuki Nawa},
  journal={Neuroscience Research},
  year={2004},
  volume={50},
  pages={67-75}
}
Maternal stress, viral infection, and obstetric complications, which trigger cytokine signaling, are hypothesized to be involved in schizophrenia and its related disorders. The etiologic contribution of individual cytokines to such psychiatric disorders, however, remains to be evaluated. To estimate the impact of peripheral cytokine challenge on neurobehavioral development, we examined effects of four proinflammatory cytokines on rat neonates and their later behavioral performance. Sublethal… CONTINUE READING

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