Perinatal hypoxia enhances cyclic adenosine monophosphate-mediated BKCa channel activation in adult murine pulmonary artery.

@article{Marino2011PerinatalHE,
  title={Perinatal hypoxia enhances cyclic adenosine monophosphate-mediated BKCa channel activation in adult murine pulmonary artery.},
  author={Mathieu Marino and J. L. B{\'e}ny and Anne-Christine Peyter and Giacomo Diaceri and J. Tols{\'a}},
  journal={Journal of cardiovascular pharmacology},
  year={2011},
  volume={57 2},
  pages={
          154-65
        }
}
Exposure to perinatal hypoxia results in alteration of the adult pulmonary circulation, which is linked among others to alterations in K(+) channels in pulmonary artery (PA) smooth muscle cells. In particular, large conductance Ca(2+)-activated K(+) (BK(Ca)) channels protein expression and activity were increased in adult PA from mice born in hypoxia compared with controls. We evaluated long-term effects of perinatal hypoxia on the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA… CONTINUE READING