Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat

@inproceedings{McKinnell2013PerinatalGC,
  title={Perinatal germ cell development and differentiation in the male marmoset (Callithrix jacchus): similarities with the human and differences from the rat},
  author={Chris McKinnell and Rod T Mitchell and Keith D. Morris and Richard A. Anderson and Chris JH. Kelnar and W. Hamish B. Wallace and Richard M. Sharpe},
  booktitle={Human reproduction},
  year={2013}
}
STUDY QUESTION Is perinatal germ cell (GC) differentiation in the marmoset similar to that in the human? SUMMARY ANSWER In a process comparable with the human, marmoset GC differentiate rapidly after birth, losing OCT4 expression after 5-7 weeks of age during mini-puberty. WHAT IS KNOWN ALREADY Most of our understanding about perinatal GC development derives from rodents, in which all gonocytes (undifferentiated GC) co-ordinately lose expression of the pluripotency factor OCT4 and stop… CONTINUE READING