Perinatal bisphenol A exposure beginning before gestation enhances allergen sensitization, but not pulmonary inflammation, in adult mice.

@article{OBrien2014PerinatalBA,
  title={Perinatal bisphenol A exposure beginning before gestation enhances allergen sensitization, but not pulmonary inflammation, in adult mice.},
  author={Edmund O'Brien and Ingrid L. Bergin and Dana C Dolinoy and Zbigniew Zaslona and Roderick J. A. Little and Yebin Tao and Marc Peters-Golden and Peter Mancuso},
  journal={Journal of developmental origins of health and disease},
  year={2014},
  volume={5 2},
  pages={121-31}
}
Bisphenol A (BPA), a monomer of polycarbonate plastics and epoxide resin, is a high-production-volume chemical implicated in asthma pathogenesis when exposure occurs to the developing fetus. However, few studies have directly examined the effect of in utero and early-life BPA exposure on the pathogenesis of asthma in adulthood. This study examines the influence of perinatal BPA exposure through maternal diet on allergen sensitization and pulmonary inflammation in adult offspring. Two weeks… CONTINUE READING