Perinatal asphyxia-induced changes in rat brain tyrosine hydroxylase-immunoreactive cell body number: effects of nicotine treatment.

@article{Chen1997PerinatalAC,
  title={Perinatal asphyxia-induced changes in rat brain tyrosine hydroxylase-immunoreactive cell body number: effects of nicotine treatment.},
  author={Yunying Chen and Mario Herrera-Marschitz and B{\"o}rje Bjelke and Mariann Blum and Johann Gross and Kurt Gerok Andersson},
  journal={Neuroscience letters},
  year={1997},
  volume={221 2-3},
  pages={77-80}
}
Perinatal asphyxia (15-22 min) was induced to male Sprague-Dawley rat pups during the last day of gestation and the surviving pups were sacrificed at 4 weeks of age. Brain sections were stained for tyrosine hydroxylase immunoreactivity and Cresyl violet. With increasing duration of perinatal asphyxia a reduction in the number of tyrosine hydroxylase immunoreactive (TH-IR) nerve cell bodies was found in the locus ceruleus, probably reflecting an increased death of noradrenaline nerve cell bodies… CONTINUE READING