Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins

  title={Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins},
  author={Mario Herrera-Marschitz and Paola Morales and Lisette Leyton and Diego A. Bustamante and Verena Klawitter and Pablo Espina-Marchant and Camilo Allende and Francisco Lisboa and Gabriel Cunich and Antonella Jara-Cavieres and Tanya Neira and Manuel A. Guti{\'e}rrez-Hern{\'a}ndez and V{\'i}ctor Gonz{\'a}lez-Lira and Nicola Simola and Andrea Schmitt and Micaela Morelli and R. Andrew Tasker and Peter J. Gebicke-Haerter},
  booktitle={Neurotoxicity Research},
Delivery is a stressful and risky event menacing the newborn. The mother-dependent respiration has to be replaced by autonomous pulmonary breathing immediately after delivery. If delayed, it may lead to deficient oxygen supply compromising survival and development of the central nervous system. Lack of oxygen availability gives rise to depletion of NAD+ tissue stores, decrease of ATP formation, weakening of the electron transport pump and anaerobic metabolism and acidosis, leading necessarily… CONTINUE READING


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