Perinatal anti-androgen treatment and genotype affect the mesotelencephalic dopamine system and behavior in mice.

@article{Vadsz1988PerinatalAT,
  title={Perinatal anti-androgen treatment and genotype affect the mesotelencephalic dopamine system and behavior in mice.},
  author={Csaba Vad{\'a}sz and G. Kobor and P{\'e}ter Kabai and Istv{\'a}n Szir{\'a}ki and Imre Vad{\'a}sz and Abel Lajtha},
  journal={Hormones and behavior},
  year={1988},
  volume={22 4},
  pages={528-39}
}
Sex and strain differences in tyrosine hydroxylase activity (TH) of brain dopamine systems have been reported for mice. To investigate if there might be a causal relationship between perinatal androgen secretion and regional mesotelencephalic TH activity, BALB/cJ and C57BL/6ByJ male mice were treated perinatally with cyproterone, a steroidal anti-androgen (or vehicle), and orchiectomized at 1 month of age. Two-way analysis of variance indicated significant treatment and strain effects in the… CONTINUE READING