Perinatal Programming of Asthma: The Role of Gut Microbiota

@article{Azad2012PerinatalPO,
  title={Perinatal Programming of Asthma: The Role of Gut Microbiota},
  author={Meghan B. Azad and Anita L. Kozyrskyj},
  journal={Clinical and Developmental Immunology},
  year={2012},
  volume={2012}
}
Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is… 

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References

SHOWING 1-10 OF 123 REFERENCES
Programming infant gut microbiota: influence of dietary and environmental factors.
Gut microbiota and probiotics in maternal and infant health.
  • Y. Sanz
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2011
TLDR
In this context, intentional modulation of microbiota composition through the use of probiotics during the perinatal and early postnatal period has been proposed as a possible dietary strategy to reduce risk of disease.
Fetal Epigenetic Mechanisms and Innate Immunity in Asthma
TLDR
A better understanding of fetal immuno-maturation conditions will provide the basis for the development of novel allergo-protective clinical strategies.
Epigenetics and prenatal influences on asthma and allergic airways disease.
TLDR
This work examines the epigenetic regulation of immune development and the early immune profiles that contribute to allergic risk, and reviews new evidence that key environmental exposures can induce epigenetic changes in gene expression and alter disease risk.
Influence of mode of delivery on gut microbiota composition in seven year old children
TLDR
Caesarean born infants have a more slowly diversifying microbiota, with differences reported from normally born infants, even after six months of age.
The importance of the development of the intestinal microbiota in infancy
TLDR
The available probiotics for prevention of atopic disease are disappointing, and the results with prebiotics need further confirmation, and new studies on the relation between gut microbiota and disease should consider asthma and atopic dermatitis separately.
The developing intestinal microbiome and its relationship to health and disease in the neonate
TLDR
Some of the effects of medical manipulations such as antibiotics, probiotics, prebiotics and C-section versus vaginal delivery on the intestinal microbiota are discussed.
Fetal Programming: Early-life Modulations that Affect Adult Outcomes
TLDR
This review examines the social, genetic, and environmental factors that are associated with fetal programming of asthma and presents recent studies from the laboratory that strengthen these observations.
The Role of Microbes in Developmental Immunologic Programming
TLDR
Recent observations from a variety of fields help support the expansion of the “fetal programming hypothesis” to a host-microbe corollary that microbe-host interactions at critical windows influence the future immune phenotype, the maintenance of immune health, and the development of immune-mediated disease.
Early life exposures: impact on asthma and allergic disease
TLDR
This overview highlights environmental exposures during the in-utero and ex-UTero time periods that are potential stimuli for the early programming of asthma and allergy.
...
...