Perinatal Programming of Asthma: The Role of Gut Microbiota

  title={Perinatal Programming of Asthma: The Role of Gut Microbiota},
  author={Meghan B. Azad and Anita L. Kozyrskyj},
  journal={Clinical and Developmental Immunology},
Perinatal programming, a dominant theory for the origins of cardiovascular disease, proposes that environmental stimuli influence developmental pathways during critical periods of prenatal and postnatal development, inducing permanent changes in metabolism. In this paper, we present evidence for the perinatal programming of asthma via the intestinal microbiome. While epigenetic mechanisms continue to provide new explanations for the programming hypothesis of asthma development, it is… 

Tables from this paper

The Infant Gut Microbiota and Risk of Asthma: The Effect of Maternal Nutrition during Pregnancy and Lactation
The specific aim of this mini review is summarizing the current knowledge regarding the effect of maternal nutrition during pregnancy and lactation on the infant gut microbiota composition, and whether it has implications for asthma development.
The infant microbiome development: mom matters.
Fetal programming of overweight through the microbiome: boys are disproportionately affected
It is proposed that pregnancy overweight influences the compositional structure of gut microbiota in infants through vertical transfer of microbiota and/or their metabolites during pregnancy, delivery and breastfeeding.
The Prebiotic and Probiotic Properties of Human Milk: Implications for Infant Immune Development and Pediatric Asthma
The latest evidence, mechanisms and hypotheses for the synergistic and/or additive effects of milk microbiota and HMOs in protecting against pediatric asthma are reviewed.
Impact of altered early infant gut microbiota following breastfeeding and delivery mode on allergic diseases.
It was proposed that vaginal delivery and breastfeeding have remarkable effects on reducing allergic diseases and the consumption of probiotic productions by the mother during and after pregnancy possibly induces beneficial impacts on attenuating the allergic diseases.
Early development of the gut microbiome and immune-mediated childhood disorders.
The review will discuss recent findings on the environmental factors that influence development of gut microbiota during infancy and its potential impact on some immune-related diseases in childhood.
Chapter 3 Impact of maternal prenatal psychosocial stress and maternal obesity on infant microbiota
The current understanding of how PNS and maternal pregnancy obesity may affect maternal gut microbiota and consequently infant microbiota and health is reviewed and recommendations for clinical practice and future research are offered.
Microbial ecology and host-microbiota interactions during early life stages
It is concluded that the exposure to the adequate microbes early in gestation and neonatal period seems to have a relevant role in health and probiotic interventions aiming to reduce the risk of immune-mediated diseases may appear effective during early life.
The infant gut microbiome as a microbial organ influencing host well-being
The current state of the art regarding the infant gut microbiota and the role of key commensal microorganisms like bifidobacteria in the establishment of the first microbial communities in the human gut are presented.


Programming infant gut microbiota: influence of dietary and environmental factors.
Gut microbiota and probiotics in maternal and infant health.
  • Y. Sanz
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2011
In this context, intentional modulation of microbiota composition through the use of probiotics during the perinatal and early postnatal period has been proposed as a possible dietary strategy to reduce risk of disease.
Fetal Epigenetic Mechanisms and Innate Immunity in Asthma
A better understanding of fetal immuno-maturation conditions will provide the basis for the development of novel allergo-protective clinical strategies.
Epigenetics and prenatal influences on asthma and allergic airways disease.
This work examines the epigenetic regulation of immune development and the early immune profiles that contribute to allergic risk, and reviews new evidence that key environmental exposures can induce epigenetic changes in gene expression and alter disease risk.
Influence of mode of delivery on gut microbiota composition in seven year old children
Caesarean born infants have a more slowly diversifying microbiota, with differences reported from normally born infants, even after six months of age.
The importance of the development of the intestinal microbiota in infancy
The available probiotics for prevention of atopic disease are disappointing, and the results with prebiotics need further confirmation, and new studies on the relation between gut microbiota and disease should consider asthma and atopic dermatitis separately.
The developing intestinal microbiome and its relationship to health and disease in the neonate
Some of the effects of medical manipulations such as antibiotics, probiotics, prebiotics and C-section versus vaginal delivery on the intestinal microbiota are discussed.
Fetal Programming: Early-life Modulations that Affect Adult Outcomes
This review examines the social, genetic, and environmental factors that are associated with fetal programming of asthma and presents recent studies from the laboratory that strengthen these observations.
The Role of Microbes in Developmental Immunologic Programming
Recent observations from a variety of fields help support the expansion of the “fetal programming hypothesis” to a host-microbe corollary that microbe-host interactions at critical windows influence the future immune phenotype, the maintenance of immune health, and the development of immune-mediated disease.
Early life exposures: impact on asthma and allergic disease
This overview highlights environmental exposures during the in-utero and ex-UTero time periods that are potential stimuli for the early programming of asthma and allergy.