Perinatal MK-801 treatment affects age-related changes in locomotor activity from childhood to later adulthood in rats.

@article{Schiffelholz2004PerinatalMT,
  title={Perinatal MK-801 treatment affects age-related changes in locomotor activity from childhood to later adulthood in rats.},
  author={Thomas Schiffelholz and Dunja Hinze-Selch and Josef Bernd Aldenhoff},
  journal={Neuroscience letters},
  year={2004},
  volume={360 3},
  pages={157-60}
}
Neuronal degeneration underlying the pathology of schizophrenia is already present during childhood. However, most of these studies were done in adult humans or animals. The present study therefore investigated age-related changes of behavior in an innovative version of the Open Field Maze following perinatal chronic administration of the noncompetitive N-methyl-D-aspartate antagonist MK-801. The waxing and waning pattern of locomotor activity during aging with a peak around the age of 90 days… CONTINUE READING

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