Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats.

@article{Racasan2004PerinatalLA,
  title={Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats.},
  author={Simona Racasan and Branko Braam and Dionne M. van der Giezen and Roel Goldschmeding and Peter C. A. M. den Boer and Hein A. Koomans and Jaap A. Joles},
  journal={Hypertension},
  year={2004},
  volume={44 1},
  pages={83-8}
}
Embryo cross-transplantation and cross-fostering between spontaneously hypertensive rats (SHR) and normotensive rats (WKY) suggest that perinatal environment modulates the genetically determined phenotype. In SHR the balance between NO and reactive oxygen species (ROS) is disturbed. We hypothesized that increasing NO and diminishing ROS in perinatal life would ameliorate hypertension in adult SHR. Pregnant SHR and WKY and their offspring received l-arginine plus antioxidants (vitamin C, vitamin… CONTINUE READING
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in elderly WKY is reversed with L - arginine and ACE inhibition

  • J Eriksson, T Forsen, J Tuomilehto, C Osmond, D Barker
  • 2001

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