Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson's Disease.

@article{Kostrzewa2016Perinatal6T,
  title={Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson's Disease.},
  author={John P. Kostrzewa and Rose Anna Kostrzewa and Richard M. Kostrzewa and Ryszard Brus and Przemysław G Nowak},
  journal={Current topics in behavioral neurosciences},
  year={2016},
  volume={29},
  pages={
          313-332
        }
}
The classic rodent model of Parkinson's disease (PD) is produced by unilateral lesioning of pars compacta substantia nigra (SNpc) in adult rats, producing unilateral motor deficits which can be assessed by dopamine (DA) D2 receptor (D2-R) agonist induction of measurable unilateral rotations. Bilateral SNpc lesions in adult rats produce life-threatening aphagia, adipsia, and severe motor disability resembling paralysis-a PD model that is so compromised that it is seldom used. Described in this… CONTINUE READING

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