Perinatal 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Sensitizes Offspring to Angiotensin II-induced Hypertension

@article{Aragon2008Perinatal2E,
  title={Perinatal 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Sensitizes Offspring to Angiotensin II-induced Hypertension},
  author={Andrea C. Aragon and M. Beth Goens and Eleanor Carbett and Mary K. Walker},
  journal={Cardiovascular Toxicology},
  year={2008},
  volume={8},
  pages={145-154}
}
In utero and lactational exposure of mice to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) leads to cardiac hypertrophy and hydronephrosis in adulthood. We tested the hypothesis that perinatal TCDD exposure increases the susceptibility to cardiovascular disease when offspring are exposed to a common cardiovascular disease risk factor, angiotensin II (Ang II). Pregnant C57BL/6N mice were exposed to corn oil (control) or 6.0 μg/kg TCDD on gestation day 14.5. Male offspring were then exposed to a… CONTINUE READING