Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.

@article{Souza2007PerilipinRT,
  title={Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue.},
  author={Sandra C Souza and Marcelo Augusto Christoffolete and Miriam Oliveira Ribeiro and Hideaki Miyoshi and Katherine J. Strissel and Zlatina S. Stancheva and Nicole H. Rogers and Tara M. D'Eon and James W. Perfield and Hitomi Imachi and Martin S. Obin and Antonio Carlos Mugayar Bianco and Andrew S Greenberg},
  journal={Journal of lipid research},
  year={2007},
  volume={48 6},
  pages={
          1273-9
        }
}
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis). NE-induced lipolysis is mediated by protein kinase A (PKA)-dependent phosphorylation of perilipin, a lipid droplet-associated protein that is the major regulator of lipolysis. We investigated the role of perilipin PKA phosphorylation in BAT NE-stimulated thermogenesis using… CONTINUE READING

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