Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels

@inproceedings{Bosma2012Perilipin2I,
  title={Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels},
  author={Madeleen Bosma and Matthijs K C Hesselink and Lauren M Sparks and S. Timmers and Maria Jo{\~a}o Ferraz and Frits Mattijssen and Denis H A van Beurden and Gert Schaart and Marc H. de Baets and Fons K C P Verheyen and Sander Kersten and Patrick Schrauwen},
  booktitle={Diabetes},
  year={2012}
}
Type 2 diabetes is characterized by excessive lipid storage in skeletal muscle. Excessive intramyocellular lipid (IMCL) storage exceeds intracellular needs and induces lipotoxic events, ultimately contributing to the development of insulin resistance. Lipid droplet (LD)-coating proteins may control proper lipid storage in skeletal muscle. Perilipin 2 (PLIN2/adipose differentiation-related protein [ADRP]) is one of the most abundantly expressed LD-coating proteins in skeletal muscle. Here we… CONTINUE READING

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