Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation.

@article{Engel2008PerifosineIG,
  title={Perifosine inhibits growth of human experimental endometrial cancers by blockade of AKT phosphorylation.},
  author={J{\"o}rg Engel and Arnd Honig and Tanja Sch{\"o}nhals and Claudia Weidler and Sebastian F. M. H{\"a}usler and Mathias Krockenberger and Thomas G. P. Grunewald and Yvonne Dombrowski and Lorenz Rieger and Johannes Dietl and J{\"o}rg Wischhusen},
  journal={European journal of obstetrics, gynecology, and reproductive biology},
  year={2008},
  volume={141 1},
  pages={64-9}
}
OBJECTIVE Perifosine is an orally active alkylphospholipid analog, which has shown anti-tumor activity in a variety of cancers by inhibition of AKT phosphorylation. The objective of the current study was to evaluate its efficacy in in vitro models of human endometrial cancer. STUDY DESIGN The effect of 10microM and 40microM perifosine on AKT phophorylation in human endometrial cancer cell lines Ishikawa and HEC 1A was determined by Western blotting. To screen for a putative anti-tumor effect… CONTINUE READING