Pericyst may be a new pharmacological and therapeutic target for hydatid disease.

@article{Wu2011PericystMB,
  title={Pericyst may be a new pharmacological and therapeutic target for hydatid disease.},
  author={Xiangwei Wu and Xue-ling Chen and Shi-Jie Zhang and Xi Zhang and Hong Sun and Xin-yu Peng},
  journal={Chinese medical journal},
  year={2011},
  volume={124 18},
  pages={2857-62}
}
BACKGROUND Most hydatid cysts with calcified walls are biologically and clinically silent and inactive. Transforming growth factor-beta 1 (TGF-β1) plays a critical role in the calcification process of cells. The aim of this study was to assess the effect of modulating TGF-β1 signaling on the calcification of hydatid cysts. METHODS Pericyst cells isolated from hepatic hydatid cysts were cultured with osteogenic media. These cells were assessed for alkaline phosphatase activity and… CONTINUE READING