Pericentromeric sister chromatid cohesion promotes kinetochore biorientation.

  title={Pericentromeric sister chromatid cohesion promotes kinetochore biorientation.},
  author={Tessie M Ng and William G Waples and Brigitte D. Lavoie and Sue Biggins},
  journal={Molecular biology of the cell},
  volume={20 17},
Accurate chromosome segregation depends on sister kinetochores making bioriented attachments to microtubules from opposite poles. An essential regulator of biorientation is the Ipl1/Aurora B protein kinase that destabilizes improper microtubule-kinetochore attachments. To identify additional biorientation pathways, we performed a systematic genetic analysis between the ipl1-321 allele and all nonessential budding yeast genes. One of the mutants, mcm21Delta, precociously separates… CONTINUE READING


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