Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the Centrosome

@article{Dictenberg1998PericentrinA,
  title={Pericentrin and γ-Tubulin Form a Protein Complex and Are Organized into a Novel Lattice at the Centrosome },
  author={Jason B. Dictenberg and Wendy Eileen Zimmerman and Cynthia A. Sparks and Aaron Young and Charles Vidair and Yixian Zheng and Walter A. Carrington and Fredric S. Fay and Stephen John Doxsey},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={141},
  pages={163 - 174}
}
Pericentrin and gamma-tubulin are integral centrosome proteins that play a role in microtubule nucleation and organization. In this study, we examined the relationship between these proteins in the cytoplasm and at the centrosome. In extracts prepared from Xenopus eggs, the proteins were part of a large complex as demonstrated by sucrose gradient sedimentation, gel filtration and coimmunoprecipitation analysis. The pericentrin-gamma-tubulin complex was distinct from the previously described… CONTINUE READING

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