Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1.

@article{Muramatsu2016PericentricHF,
  title={Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1.},
  author={Daisuke Muramatsu and Hiroshi Kimura and Kaoru Kotoshiba and Makoto Tachibana and Yoichi Shinkai},
  journal={Cell structure and function},
  year={2016},
  volume={41 2},
  pages={
          145-152
        }
}
Pericentric regions form epigenetically organized, silent heterochromatin structures that accumulate histone H3 lysine 9 tri-methylation (H3K9me3) and heterochromatin protein 1 (HP1), a methylated H3K9-binding protein. At pericentric regions, Suv39h is the major enzyme that generates H3K9me3. Suv39h also interacts directly with HP1. However, the importance of HP1 interaction for Suv39h-mediated H3K9me3 formation at the pericentromere is not well characterized. To address this question, we… CONTINUE READING
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Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

RNAi and heterochromatin assembly.

VIEW 1 EXCERPT

A transcription factor–based mechanism for mouse heterochromatin formation

VIEW 1 EXCERPT