Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis

@article{Yeh2008PericentricCI,
  title={Pericentric Chromatin Is Organized into an Intramolecular Loop in Mitosis},
  author={Elaine Yeh and Julian Haase and Leocadia V Paliulis and Ajit P. Joglekar and Lisa Bond and David C. Bouck and Edward D. Salmon and Kerry S. Bloom},
  journal={Current Biology},
  year={2008},
  volume={18},
  pages={81-90}
}
BACKGROUND Cohesin proteins link sister chromatids and provide the basis for tension between bioriented sister chomatids in mitosis. Cohesin is concentrated at the centromere region of the chromosome despite the fact that sister centromeres can be separated by 800 nm in vivo. The function of cohesin at sites of separated DNA is unknown. RESULTS We provide evidence that the kinetochore promotes the organization of pericentric chromatin into a cruciform in mitosis such that centromere-flanking… CONTINUE READING

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We provide evidence that the kinetochore promotes the organization of pericentric chromatin into a cruciform in mitosis such that centromere - flanking DNA adopts an intramolecular loop , whereas sister - chromatid arms are paired intermolecularly .
Two centromere loops ( one from each sister chromatid ) are stretched between the ends of sister - kinetochore microtubules along the spindle axis .
Two centromere loops ( one from each sister chromatid ) are stretched between the ends of sister - kinetochore microtubules along the spindle axis .
We provide evidence that the kinetochore promotes the organization of pericentric chromatin into a cruciform in mitosis such that centromere - flanking DNA adopts an intramolecular loop , whereas sister - chromatid arms are paired intermolecularly .
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