Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.

@article{Owen2010PericellularAO,
  title={Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.},
  author={Kate A. Owen and Deyi Qiu and Juliano V. Alves and Andrew M. Schumacher and Lynette M. Kilpatrick and Jun Li and Jennifer L. Harris and Vincent Ellis},
  journal={The Biochemical journal},
  year={2010},
  volume={426 2},
  pages={
          219-28
        }
}
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity. The activating proteases are key components of its regulation, but controversy surrounds their identity. Using quantitative analysis we found no evidence for activation by uPA (urokinase plasminogen activator), despite reports that this is a principal activator of pro-HGF. This was unaffected by a wide range of… CONTINUE READING

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