Periaqueductal grey mediated inhibition of responses to noxious stimulation is dynamically activated in a rat model of neuropathic pain

@article{Monhemius2001PeriaqueductalGM,
  title={Periaqueductal grey mediated inhibition of responses to noxious stimulation is dynamically activated in a rat model of neuropathic pain},
  author={Russell Monhemius and D. L Green and M. H. T Roberts and J Azami},
  journal={Neuroscience Letters},
  year={2001},
  volume={298},
  pages={70-74}
}
The periaqueductal grey (PAG) has been shown to be a major source of descending inhibition of dorsal horn cells (Textbook of Pain (1999) 309). However, few studies have demonstrated alterations in behavioural responses to noxious stimulation following inactivation of this nucleus. Many behavioural studies have looked for effects on nociceptive withdrawal thresholds in acute nociceptive tests. These tests would not reveal the presence of inhibition which is activated in response to noxious input… CONTINUE READING

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