Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat.

@article{Novellis2005PeriaqueductalGC,
  title={Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat.},
  author={Vito de Novellis and Loredana Mariani and Enza Palazzo and Daniela Vita and Ida Marabese and Maria Antonietta Scafuro and Francesca Rossi and Sabatino Maione},
  journal={Neuroscience},
  year={2005},
  volume={134 1},
  pages={269-81}
}
This study was undertaken to analyze the involvement of periaqueductal gray (PAG) cannabinoid or group I metabotropic glutamate receptors in the formalin-induced changes on the rostral ventromedial medulla (RVM) ON- and OFF-cells activities. S.c. injection of formalin into the hind paw produced a transient decrease (4-6 min) followed by a longer increase (25-35 min) in tail flick latencies. Formalin also increased basal activity in RVM ON-cells (42+/-7%) and decreased it in OFF-cells (35+/-4… CONTINUE READING