Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells.

@article{Raghavan2014PerianalIO,
  title={Perianal implantation of bioengineered human internal anal sphincter constructs intrinsically innervated with human neural progenitor cells.},
  author={Shreya Raghavan and Eiichi Miyasaka and Robert R. Gilmont and Sita Somara and Daniel Teitelbaum and Khalil N. Bitar},
  journal={Surgery},
  year={2014},
  volume={155 4},
  pages={668-74}
}
BACKGROUND The internal anal sphincter (IAS) is a major contributing factor to pressure within the anal canal and is required for maintenance of rectoanal continence. IAS damage or weakening results in fecal incontinence. We have demonstrated that bioengineered, intrinsically innervated, human IAS tissue replacements possess key aspects of IAS physiology, such as the generation of spontaneous basal tone and contraction/relaxation in response to neurotransmitters. The objective of this study is… CONTINUE READING
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