Periadventitial fat releases a vascular relaxing factor

  title={Periadventitial fat releases a vascular relaxing factor},
  author={M. L{\"o}hn and G. Dubrovska and B. Lauterbach and F. Luft and M. Gollasch and A. Sharma},
  journal={The FASEB Journal},
  pages={1057 - 1063}
  • M. Löhn, G. Dubrovska, +3 authors A. Sharma
  • Published 2002
  • Biology, Medicine
  • The FASEB Journal
  • Virtually all blood vessels are surrounded by adventitial fat. Adipocytes produce a host of vasoactive substances that may influence vascular contraction. We tested whether or not perivascular adipose tissue modulates contraction of aortic ring preparations. We studied aortic rings surrounded by periadventitial adipose tissue from adult Sprague‐Dawley rats. At a maximum concentration of 300 nM angiotensin II, 6.5 μM serotonin, and 5 μM phenyleph‐rine, the contractile response of intact rings… CONTINUE READING
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