Periadventitial fat releases a vascular relaxing factor
@article{Lhn2002PeriadventitialFR, title={Periadventitial fat releases a vascular relaxing factor}, author={M. L{\"o}hn and G. Dubrovska and B. Lauterbach and F. Luft and M. Gollasch and A. Sharma}, journal={The FASEB Journal}, year={2002}, volume={16}, pages={1057 - 1063} }
Virtually all blood vessels are surrounded by adventitial fat. Adipocytes produce a host of vasoactive substances that may influence vascular contraction. We tested whether or not perivascular adipose tissue modulates contraction of aortic ring preparations. We studied aortic rings surrounded by periadventitial adipose tissue from adult Sprague‐Dawley rats. At a maximum concentration of 300 nM angiotensin II, 6.5 μM serotonin, and 5 μM phenyleph‐rine, the contractile response of intact rings… CONTINUE READING
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References
SHOWING 1-10 OF 18 REFERENCES
Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness.
- Biology, Medicine
- Clinical and experimental hypertension. Part A, Theory and practice
- 1991
- 270
- Highly Influential
Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation.
- Chemistry, Medicine
- The American journal of physiology
- 1994
- 66
A Review of the Microcirculation of Adipose Tissue: Anatomic, Metabolic, and Angiogenic Perspectives
- Biology, Medicine
- Microcirculation
- 1997
- 469
Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1995
- 51
Role of adipose tissue for cardiovascular-renal regulation in health and disease.
- Medicine
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- 2000
- 89
Coronary reactive hyperemia and adenosine-induced vasodilation are mediated partially by a glyburide-sensitive mechanism.
- Medicine
- Pharmacology
- 1992
- 44
Tissue selectivity of antidiabetic agent nateglinide: study on cardiovascular and beta-cell K(ATP) channels.
- Chemistry, Medicine
- The Journal of pharmacology and experimental therapeutics
- 1999
- 57
ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo.
- Medicine
- The American journal of physiology
- 1992
- 160
Effects of potassium channel blockers on basal vascular tone and reactive hyperemia of canine diaphragm.
- Chemistry, Medicine
- The American journal of physiology
- 1994
- 27
Glibenclamide, a putative ATP-sensitive K+ channel blocker, inhibits coronary autoregulation in anesthetized dogs.
- Medicine
- Circulation research
- 1993
- 65
- PDF