Peri-procedural use of rivaroxaban in elective percutaneous coronary intervention to treat stable coronary artery disease. The X-PLORER trial.

@article{Vranckx2015PeriproceduralUO,
  title={Peri-procedural use of rivaroxaban in elective percutaneous coronary intervention to treat stable coronary artery disease. The X-PLORER trial.},
  author={Pascal Vranckx and Frank W G Leebeek and Jan G. P. Tijssen and J. L. A. Koolen and Francis Stammen and J-P R Herman and Robbert J. de Winter and Arnoud W J van T Hof and Bianca Backx and Wietze K Lindeboom and So-Yun Kim and Bodo Kirsch and Martin van Eickels and Frank Misselwitz and Freek W. A. Verheugt},
  journal={Thrombosis and haemostasis},
  year={2015},
  volume={114 2},
  pages={258-67}
}
Patients on rivaroxaban requiring percutaneous coronary intervention (PCI) represent a clinical conundrum. We aimed to investigate whether rivaroxaban, with or without an additional bolus of unfractionated heparin (UFH), effectively inhibits coagulation activation during PCI. Stable patients (n=108) undergoing elective PCI and on stable dual antiplatelet therapy were randomised (2:2:2:1) to a short treatment course of rivaroxaban 10 mg (n=30), rivaroxaban 20 mg (n=32), rivaroxaban 10 mg plus… CONTINUE READING

6 Figures & Tables

Connections & Topics

Mentioned Connections BETA
In patients treated with rivaroxaban ( 10 or 20 mg ) and patients treated with rivaroxaban plus heparin , the levels of prothrombin fragment 1 + 2 at 2 h post - PCI were 0.16 [ 0.1 ] nmol / l ( median ) [ interquartile range , IQR ] and 0.17 [ 0.2 ] nmol / l , respectively .
In patients treated with rivaroxaban ( 10 or 20 mg ) and patients treated with rivaroxaban plus heparin , the levels of prothrombin fragment 1 + 2 at 2 h post - PCI were 0.16 [ 0.1 ] nmol / l ( median ) [ interquartile range , IQR ] and 0.17 [ 0.2 ] nmol / l , respectively .
In patients treated with rivaroxaban ( 10 or 20 mg ) and patients treated with rivaroxaban plus heparin , the levels of prothrombin fragment 1 + 2 at 2 h post - PCI were 0.16 [ 0.1 ] nmol / l ( median ) [ interquartile range , IQR ] and 0.17 [ 0.2 ] nmol / l , respectively .
In patients treated with rivaroxaban ( 10 or 20 mg ) and patients treated with rivaroxaban plus heparin , the levels of prothrombin fragment 1 + 2 at 2 h post - PCI were 0.16 [ 0.1 ] nmol / l ( median ) [ interquartile range , IQR ] and 0.17 [ 0.2 ] nmol / l , respectively .
All Topics