Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics.

@article{Horowitz1986PerhexilineMT,
  title={Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics.},
  author={John David Horowitz and S. T. B. Sia and Peter S Macdonald and Alan James Goble and William John Louis},
  journal={International journal of cardiology},
  year={1986},
  volume={13 2},
  pages={
          219-29
        }
}
Perhexiline maleate, which causes inhibition of myocardial fatty acid catabolism with a concomitant increase in glucose utilization, is particularly useful in the management of patients with severe angina pectoris. While perhexiline exerts no significant negative inotropic or dromotropic effects, its short- and long-term use has hitherto been restricted because of complex pharmacokinetics and the eventual development, in many patients, of hepatitis and peripheral neuropathy. Correlations… CONTINUE READING
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