Pergolide : A Review of its Pharmacology and Therapeutic Use in Parkinson's Disease.

@article{Markham1997PergolideA,
  title={Pergolide : A Review of its Pharmacology and Therapeutic Use in Parkinson's Disease.},
  author={A. Markham and P. Benfield},
  journal={CNS drugs},
  year={1997},
  volume={7 4},
  pages={
          328-40
        }
}
  • A. Markham, P. Benfield
  • Published 1997
  • Medicine
  • CNS drugs
  • SYNOPSIS The semisynthetic ergotine dopamine agonist pergolide has demonstrated activity at pre- and postsynaptic dopamine D2 receptors in vitro and in vivo animal studies. However, unlike other dopamine agonists such as bromocriptine, pergolide also has agonist activity at dopamine D1 receptors. Certain other pharmacological effects of pergolide, such as reduction of dopamine turnover and effects on free radical scavenging enzymes, may be relevant in the early treatment of Parkinson's disease… CONTINUE READING
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