Perfusion of rat colon with sennosides, rhein and rheinanthrone. Concentration-related histamine release.

@article{Autore1990PerfusionOR,
  title={Perfusion of rat colon with sennosides, rhein and rheinanthrone. Concentration-related histamine release.},
  author={Giuseppina Autore and Giuseppe Caliendo and Antonietta Pepe and Francesco Capasso},
  journal={European journal of pharmacology},
  year={1990},
  volume={191 1},
  pages={97-9}
}
Rat colon perfused intraluminally in vitro and in vivo released histamine into the perfusates. Histamine release was increased by rhein 0.1-10 micrograms/ml and much more by rheinanthrone 0.1-10 micrograms/ml but not by sennosides A or B 1-10 micrograms/ml. The effect of rhein and rheinanthrone was reduced by tritoqualine 20 mg/kg. This raises the possibility that laxation by senna and its derivatives involves histamine formation.