Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1-microglobulin.

@article{May2011PerfusionOH,
  title={Perfusion of human placenta with hemoglobin introduces preeclampsia-like injuries that are prevented by α1-microglobulin.},
  author={Karen Farnes May and Lena Wester Rosenl{\"o}f and Magnus G. Olsson and Magnus Centlow and Matthias M{\"o}rgelin and Ir{\'e}ne Larsson and Martin Cederlund and Sigurbj{\"o}rg Rutard{\'o}ttir and Werner Siegmund and Henning Schneider and Bo {\AA}kerstr{\"o}m and Stefan Rocco Hansson},
  journal={Placenta},
  year={2011},
  volume={32 4},
  pages={323-32}
}
BACKGROUND Preeclamptic women have increased plasma levels of free fetal hemoglobin (HbF), increased gene expression of placental HbF and accumulation of free HbF in the placental vascular lumen. Free hemoglobin (Hb) is pro-inflammatory, and causes oxidative stress and tissue damage. METHODOLOGY To show the impact of free Hb in PE, we used the dual ex… CONTINUE READING