Perfusion improves tissue architecture of engineered cardiac muscle.

  title={Perfusion improves tissue architecture of engineered cardiac muscle.},
  author={Rebecca Lyn Carrier and Maria A Rupnick and Robert Langer and Frederick J. Schoen and Lisa E. Freed and Gordana Vunjak-Novakovic},
  journal={Tissue engineering},
  volume={8 2},
Cardiac muscle with a certain threshold thickness, uniformity of tissue architecture, and functionality would expand the therapeutic options currently available to patients with congenital or acquired cardiac defects. Cardiac constructs cultured in well-mixed medium had an approximately 100-microm-thick peripheral tissue-like region around a relatively cell-free interior, a structure consistent with the presence of concentration gradients within the tissue. We hypothesized that direct perfusion… CONTINUE READING