Perfused Three-dimensional Organotypic Culture of Human Cancer Cells for Therapeutic Evaluation

@inproceedings{Wan2017PerfusedTO,
  title={Perfused Three-dimensional Organotypic Culture of Human Cancer Cells for Therapeutic Evaluation},
  author={Xiao Wan and Steven J. Ball and Frances W. Willenbrock and Shaoyang Anthony Yeh and Nikola Vitanov Vlahov and Delia Koennig and Marcus Green and Graham Brown and Sanjeeva Jeyaretna and Zhaohui Li and Zhanfeng Cui and Hua Ye and Eric O'Neill},
  booktitle={Scientific Reports},
  year={2017}
}
Pharmaceutical research requires pre-clinical testing of new therapeutics using both in-vitro and in-vivo models. However, the species specificity of non-human in-vivo models and the inadequate recapitulation of physiological conditions in-vitro are intrinsic weaknesses. Here we show that perfusion is a vital factor for engineered human tissues to recapitulate key aspects of the tumour microenvironment. Organotypic culture and human tumour explants were allowed to grow long-term (14–35 days… CONTINUE READING
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