Performance of the flow cytometric E-screen assay in screening estrogenicity of pure compounds and environmental samples.

@article{Vanparys2010PerformanceOT,
  title={Performance of the flow cytometric E-screen assay in screening estrogenicity of pure compounds and environmental samples.},
  author={Caroline Vanparys and Sophie Depiereux and St{\'e}phanie Nadzialek and Johan Robbens and Ronny Blust and Patrick Kestemont and Wim M. De Coen},
  journal={The Science of the total environment},
  year={2010},
  volume={408 20},
  pages={
          4451-60
        }
}
In vitro estrogenicity screens are believed to provide a first prioritization step in hazard characterization of endocrine disrupting chemicals. When applied to complex environmental matrices or mixture samples, they have been indicated valuable in estimating the overall estrogen-mimicking load. In this study, the performance of an adapted format of the classical E-screen or MCF-7 cell proliferation assay was profoundly evaluated to rank pure compounds as well as influents and effluents of… CONTINUE READING
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