Performance of mitochondrial DNA mutations detecting early stage cancer

  title={Performance of mitochondrial DNA mutations detecting early stage cancer},
  author={John P. Jakupciak and Samantha Maragh and Maura E Markowitz and Alissa K. Greenberg and Mohammad Obaidul Hoque and Anirban Maitra and Peter E. Barker and Paul A. Wagner and William Rom and Sudhir K. Srivastava and David Sidransky and Catherine D. O'Connell},
  journal={BMC Cancer},
  pages={285 - 285}
Mutations in the mitochondrial genome (mtgenome) have been associated with cancer and many other disorders. These mutations can be point mutations or deletions, or admixtures (heteroplasmy). The detection of mtDNA mutations in body fluids using resequencing microarrays, which are more sensitive than other sequencing methods, could provide a strategy to measure mutation loads in remote anatomical sites. We determined the mtDNA mutation load in the entire mitochondrial genome of 26 individuals… CONTINUE READING
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