Performance of genotypic tropism testing in clinical practice using the enhanced sensitivity version of Trofile as reference assay: results from the OSCAR Study Group.

@article{Svicher2010PerformanceOG,
  title={Performance of genotypic tropism testing in clinical practice using the enhanced sensitivity version of Trofile as reference assay: results from the OSCAR Study Group.},
  author={Valentina Svicher and Roberta D'arrigo and Claudia Alteri and Massimo Andreoni and Gioacchino Angarano and Andrea Antinori and Guido Antonelli and Patrizia Bagnarelli and Fausto Baldanti and Ada Bertoli and Marco Borderi and Enzo Boeri and Isabella Bonn and Bianca Bruzzone and Anna Paola Callegaro and Roberta Cammarota and Filippo Canducci and Francesca Ceccherini-Silberstein and Massimo Clementi and Antonella d'Arminio Monforte and Andrea De Luca and Antonio Di Biagio and Simona Di Gianbenedetto and Giovanni di Perri and Massimo di Pietro and Lavinia Fabeni and Giovanni Fadda and Massimo Galli and William Gennari and Valeria Ghisetti and Andrea Giacometti and Andrea Gori and Francesco Leoncini and Franco Maggiolo and Renato Maserati and Francesco Mazzotta and Valeria Micheli and Genny Meini and Laura Monno and Cristina Mussini and Silvia Nozza and Stefania Paolucci and Saverio Giuseppe Parisi and Monica Pecorari and Daniele Vazquez Pizzi and Tiziana Quirino and Maria Carla Re and Giuliano Rizzardini and Rosaria Santangelo and Alessandro Soria and Francesca Stazi and G Sterrantino and Ombretta Turriziani and Claudio Viscoli and Vincenzo Vullo and Adriano Lazzarin and Carlo Federico Perno},
  journal={The new microbiologica},
  year={2010},
  volume={33 3},
  pages={
          195-206
        }
}
OBJECTIVE The goal of the OSCAR programme is to evaluate the performances of genotypic HIV-1 tropism testing in clinical practice using the enhanced sensitivity version of Trofile (ESTA) as reference-assay. METHODS HIV-1 coreceptor-usage was assessed using plasma samples from 406 HIV-1 infected patients by ESTA and by gp120 V3 population-sequencing followed by Geno2pheno (set at a False Positive Rate [FPR] of 10% and 5%). RESULTS ESTA was successful in 365 (89.9%) samples indicating R5 in… CONTINUE READING

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