Performance of different microsatellite marker panels for detection of mismatch repair-deficient colorectal tumors.

Abstract

BACKGROUND Colorectal tumors caused by failure of the DNA mismatch repair system commonly show microsatellite instability. Our goals were to compare the performance of two panels of markers (a panel previously recommended by the National Cancer Institute [NCI] and a pentaplex of mononucleotide repeats) and to devise the simplest diagnostic strategy for… (More)

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