Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimens

@inproceedings{Les2014PerformanceCO,
  title={Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimens},
  author={Inger Marie L\oes and Heike Immervoll and Jon-Helge Angelsen and Arild Horn and J{\"u}rgen Geisler and Christian Busch and Per Eystein L\onning and Stian Knappskog},
  booktitle={Tumor Biology},
  year={2014}
}
Personalized cancer care requires reliable biomarkers. While the BRAF V600E mutation is implemented in the clinic, no method for its detection has so far been established as reference. We aimed to perform a comprehensive comparison of three methods currently being used for V600E detection in clinical samples. We analysed genomic DNA from 127 malignant melanomas (77 patients) and 389 tumours from 141 colorectal cancer patients (383 liver metastases and 6 primary tumours) by Sanger sequencing and… CONTINUE READING

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