Perforin-mediated lysis of tumor cells by Mycobacterium bovis Bacillus Calmette-Guérin-activated killer cells.

  title={Perforin-mediated lysis of tumor cells by Mycobacterium bovis Bacillus Calmette-Gu{\'e}rin-activated killer cells.},
  author={Sven Brandau and Henrik Suttmann and Josef Riemensberger and Ulrike Seitzer and Josh Arnold and Christoph Durek and Dieter Jocham and H. D. Flad and Andreas Boehle},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={6 9},
Immunotherapy with Bacillus Calmette-Guérin (BCG) is clinically established in the treatment of superficial bladder cancer. In our attempt to clarify the underlying immunological mechanism, we could previously show that stimulation of PBMC with BCG leads to the generation of cytotoxic BCG-activated killer (BAK) cells. Among others, these BAK cells as well as lymphokine-activated killer (LAK) cells have been suggested as possible effector cells during BCG therapy. To understand BCG-induced… CONTINUE READING