Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.

Abstract

BACKGROUND Residual HIV-1-infected cells are poorly eliminated from lymphoid tissue (LT) reservoirs by effector cytotoxic T lymphocytes (eCTL) despite antiretroviral therapy. Perforin and granzyme A (grA) constitute major effector molecules within eCTL granules that induce apoptosis and lysis of virally infected cells. OBJECTIVE Expression of perforin and… (More)

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Cite this paper

@article{Andersson1999PerforinIN, title={Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection.}, author={J. Sebastian Andersson and Hassan Sh. Behbahani and Jeffrey A. Lieberman and Elizabeth Connick and Alan L. Landay and Bruce W. Patterson and Anders S{\"o}nnerborg and Karin Lor{\'e} and Stefania Uccini and Thomas E. Fehniger}, journal={AIDS}, year={1999}, volume={13 11}, pages={1295-303} }