Perforin is essential for control of ectromelia virus but not related poxviruses in mice.

@article{Mllbacher1999PerforinIE,
  title={Perforin is essential for control of ectromelia virus but not related poxviruses in mice.},
  author={Arno M{\"u}llbacher and Ron Tha Hla and Crisan Museteanu and Markus Michael Simon},
  journal={Journal of virology},
  year={1999},
  volume={73 2},
  pages={1665-7}
}
Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzymes in blood. Cowpox virus on the other hand is more virulent in the presence of perforin than in its absence. An additional lack of granzyme A which together with perforin is a constituent of… CONTINUE READING
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Granzyme A is essential for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

  • A. Müllbacher, K. Ebnet, R. V. Blanden, T. Stehle, C. Museteanu, M. M. Simon
  • Proc. Natl. Acad. Sci. USA
  • 1996

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