Perforin gene expression in granular lymphocyte proliferative disorders.

  title={Perforin gene expression in granular lymphocyte proliferative disorders.},
  author={Kazuo Oshimi and Yoichi Shinkai and Ko Okumura and Y Oshimi and Hideaki Mizoguchi},
  volume={75 3},
By Northern blot analysis using a cDNA clone of the perforin gene, we studied the levels of perforin mRNA in peripheral blood mononuclear cells from 11 cases of granular lymphocyte-proliferative disorders (GLPDs). The granular lymphocytes studied were characterized by morphologic, immunophenotypic, and immunogenotypic analyses. Cytolytic functions of the lymphocytes assayed included nonmajor histocompatibility complex-requiring cytotoxicity, anti-CD3-redirected cytotoxicity, antibody-dependent… CONTINUE READING

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